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成果及论文

1. Zheng J, Lang Y, Zhang Q, Cui D, Sun H, Jiang J, Jiang L, Chen Z, Zhang R, Gao Y, Tian W, Wu W, *Tang J, *Chen Z. Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Gene & Development Accepted (IF=12.63) 2. Geng Y, Wang X, Yang L, Sun H, Wang Y, Zhao Y, She R, Wang MX, *Wang DX, *Tang J. (2015)Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo. PLoS One 10(6):e0128928. (IF=3.534) 3. Xu Z, Cheng W, Guo K, Yu J, *Shen J, *Tang J, Yang W, *Yin M. (2015) The molecular size, shape and electric charges are essential for perylene bisimides-based DNA intercalator to localize in cell nuclei and inhibit cancer cell growth. ACS Applied Materials & Interfaces 7(18):9784-91 (IF=5.9) 4. Xu A, Qin C, Lang Y, Wang M, Lin M, Li C, Zhang S, *Tang J. (2015) A simple and rapid approach to manipulate Pseudorabies virus genome by CRISPR/Cas9 system. Biotechnology Letters 37(6):1265-72 (IF=1.73) 5. Wang Z, Xu A, Hou X, Chen F, Cao W, Yu J, Liao M, *Tang J. (2014) COP9 signalosome subunit 6 binds and inhibits avian leukosis virus integrase. Biochem Biophys Res Commun 453(3):527-32 (IF=2.281) 6. Cui D., Li LJ, Lou HJ., Sun HL, Ngai S-M, Shao GZ, and *Tang J. (2014) The ribosomal protein S26 regulates p53 activity in response to DNA damage. Oncogene 33(17):2225-35 (IF=8.559) 7. Xu Z, Guo K, Yu J, Sun H, Tang J, Shen J, Müllen K, Yang W, Yin M. (2014) A unique perylene-based DNA intercalator: localization in cell nuclei and inhibition of cancer cells and tumors. Small. 10(20):4087-92 (IF=7.51) 8. Huang C, Zhang Q, Guo XK, Yu ZB, Xu AT, Tang J, Feng WH. (2014) Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-κB essential modulator. J Virol. 88(18):10934-45 (IF=4.648) 9. Bi Y, Guo XK, Zhao H, Gao L, Wang L, Tang J, Feng WH. (2014) Highly pathogenic porcine reproductive and respiratory syndrome virus induces prostaglandin E2 production through cyclooxygenase 1, which is dependent on the ERK1/2-p-C/EBP-β pathway. J Virol. 88(5):2810-20 (IF=4.648) 10. Wang L, Hou J, Gao L, Guo XK, Yu Z, Zhu Y, Liu Y, Tang J, Zhang H, Feng WH. (2014) Attenuation of highly pathogenic porcine reproductive and respiratory syndrome virus by inserting an additional transcription unit. Vaccine. 32(43):5740-8 (IF=3.48) 11. Tang J., Agrawal T., Cheng Q., Qu L., Brewer MD., Chen J., Yang X. (2013) Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation. PLoS One 8(2):e55813 (IF=3.534) 12. Ma ZT, Wang YL, Zhao HY, Xu AT, Wang YQ, *Tang J., *Feng WH. (2013) Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Induces Apoptosis Dependent on Its 3C-Like Serine Protease Activity. PLoS One 8(7):e69387. (IF=3.534) 13. Geng YY., Monajembashi S., Shao AW., Cui D., He WY., Chen Z., Hemmerich P., *Tang J. (2012) Contribution of the C-terminal regions of Promyelocytic leukemia protein (PML) isoform II and V to PML nuclear body formation. J Biol Chem 287(36):30729-42 (cover story) (IF=4.6) 14. Li LJ., Cui D., Zheng S.J., Lou HJ., *Tang J. (2012) Regulation of Actinomycin D induced upregulation of Mdm2 in H1299 cells. DNA Repair (Amst). 11(2):112-9 (IF=3.362) 15. Fu Y., Quan R., Zhang H., Hou J., *Tang J., *Feng WH. (2012) Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Induces Interleukin-15 through the NF-κB Signaling Pathway. J Virol. 86(14):7625-36 (IF=4.648) 16. Wang J., Wang Y., Liu J., Ding L., Zhang Q., Li X., Cao H., *Tang J., *Zheng S.J. (2012) A critical role of N-myc and STAT interactor (Nmi) in Foot-and-Mouth Disease Virus (FMDV) 2C-induced apoptosis. Virus Research 170(1-2):59-65. (IF=2.827) 17. Chen K., Luo Z., *Tang J., and *Zheng S.J. (2011) A critical role of Heat shock cognate protein 70 in Apoptin-induced phosporylation of Akt. Biochem Biophys Res Commun 409:200-4 (IF=2.281) 18. *Tang J., Qu L., Pang MS., Yang X. (2010) Daxx is reciprocally regulated by Mdm2 and Hausp. Biochem Biophys Res Commun 393:542-5 (IF=2.281) 19. Pang P.,Chen FY., Tang J., Ma JC. Wang JC., Zheng S.J. (2010) Avian leukosis virus p27 inhibits tumor necrosis factor α expression in RAW264.7 macrophages after stimulation with lipopolysaccharide. Acta virologica 54: 119-124 (IF=1.03) 20. Tang J., Qu L., Zhang J., Wang W., Michaelson JS., Degenhardt Y., El-Deiry WS., and Yang X. (2006) Critical role for Daxx in regulating Mdm2. Nature Cell Biol. 8(8): 855-62 21. Tang J., Kawadler H., Yang X. (2005) Lymphocyte Life and Death: The Caspase-8 Connection. Cancer Biol Ther. 4(7): 700-2 22. Tang J., Xie W., Yang X. (2005) Association of Caspase-2 with the Promyelocytic Leukemia Protein Nuclear Bodies. Cancer Biol Ther. 4(6): 645-649 23. Tang J., Chang HY., Yang X. (2005) The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62. FEBS Lett. 579(13):2883-90